Biochem/physiol Actions

Cell permeable: yes

General description

A cell permeable, orally bioavailable, non-toxic salt form of niclosamide that acts as a reversible, mild uncoupler of mitochondria to reduce cellular energy efficiency and increase lipid oxidation. Also shown to reduce the mitochondrial membrane potential in live cells (~ 500 nM). Following oral uptake, it is distributed primarily in the liver. Improves glycemic control, improves insulin sensitivity,and reduces the level of glycated hemoglobin in C57BL/6J mice fed high fat diets. Retards the decline of plasma insulin level in db/db mice and improves their glycemic control. (150 mg/kg., p.o.). Activates AMPK and increases acetyl-CoA carboxylase phosphorylation, but does not affect the activity of gluconeogenic enzymes in the liver. Reported to reduce intracellular lipid accumulation in mice fed high fat diets.

Niclosamide Ethanolamine, NEN, AMPK activator

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Tao, H., et al. 2014. Nat. Med.20, 1263.

Packaging

25 mg in Glass bottle

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Warning

Toxicity: Standard Handling (A)